|Application ||WB, IHC-P, FC, E|
|Other Accession||Q6P0K8, Q8WNW3, Q02257, Q8SPJ1|
|Predicted||Bovine, Mouse, Pig, Rat|
|Calculated MW||81745 Da|
|Antigen Region||636-663 aa|
|Other Names||Junction plakoglobin, Catenin gamma, Desmoplakin III, Desmoplakin-3, JUP, CTNNG, DP3|
|Target/Specificity||This JUP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 636-663 amino acids from the C-terminal region of human JUP.|
|Precautions||JUP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).|
|Cellular Location||Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Cytoplasmic in a soluble and membrane-associated form|
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Provided below are standard protocols that you may find useful for product applications.
JUP is a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat.
Arnemann,J., et.al., Genomics 10 (3), 640-645 (1991)
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