|Application ||WB, IHC-P, FC, E|
|Calculated MW||198311 Da|
|Antigen Region||646-675 aa|
|Other Names||Lymphocyte antigen 75, Ly-75, C-type lectin domain family 13 member B, DEC-205, gp200-MR6, CD205, LY75, CD205, CLEC13B|
|Target/Specificity||This LY75 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 646-675 amino acids from the Central region of human LY75.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Precautions||LY75 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen- processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B-lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.|
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Provided below are standard protocols that you may find useful for product applications.
LY75 acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment. It causes reduced proliferation of B-lymphocytes.
Kato,M., et.al., Immunogenetics 47 (6), 442-450 (1998)
McKay,P.F., et.al., Eur. J. Immunol. 28 (12), 4071-4083 (1998)
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