|Application ||WB, IHC-P, E|
|Calculated MW||79710 Da|
|Antigen Region||29-57 aa|
|Other Names||Beta-adrenergic receptor kinase 2, Beta-ARK-2, G-protein-coupled receptor kinase 3, ADRBK2, BARK2, GRK3|
|Target/Specificity||This ADRBK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-57 amino acids from the N-terminal region of human ADRBK2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ADRBK2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.|
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Provided below are standard protocols that you may find useful for product applications.
ADRBK2 is the beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
Gratacos,M., et.al., Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009)
Rao,J.S., et.al., Int. J. Neuropsychopharmacol. 12 (6), 851-860 (2009)
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