|Application ||WB, IHC-P, FC, E|
|Calculated MW||119159 Da|
|Antigen Region||103-130 aa|
|Other Names||Kinesin-like protein KIF11, Kinesin-like protein 1, Kinesin-like spindle protein HKSP, Kinesin-related motor protein Eg5, Thyroid receptor-interacting protein 5, TR-interacting protein 5, TRIP-5, KIF11, EG5, KNSL1, TRIP5|
|Target/Specificity||This KIF11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-130 amino acids from the N-terminal region of human KIF11.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KIF11 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||EG5, KNSL1, TRIP5|
|Function||Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton, spindle pole|
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Provided below are standard protocols that you may find useful for product applications.
KIF11 belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis.
Tcherniuk,S., et.al., Biochem. Pharmacol. 79 (6), 864-872 (2010)
Parke,C.L., et.al., J. Biol. Chem. 285 (8), 5859-5867 (2010)
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