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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PCBD1 Antibody (Center)   

PCBD1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PCBD1 Antibody (Center) AP9111c
    Western blot analysis of PCBD1 Antibody (Center) (Cat. #AP9111c) in mouse liver tissue lysates (35ug/lane). PCBD1 (arrow) was detected using the purified Pab.
  • IHC-P - PCBD1 Antibody (Center) AP9111c
    Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with PCBD1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - PCBD1 Antibody (Center) AP9111c
    PCBD1 Antibody (Center) (Cat. #AP9111c) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P61457
Other Accession P61459, Q3ZBD3
Reactivity Human, Mouse
Predicted Bovine, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 12000 Da
Antigen Region 11-37 aa
Additional Information
Gene ID 5092
Other Names Pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Dimerization cofactor of hepatocyte nuclear factor 1-alpha, DCoH, Dimerization cofactor of HNF1, Phenylalanine hydroxylase-stimulating protein, Pterin carbinolamine dehydratase, PCD, PCBD1, DCOH, PCBD
Target/Specificity This PCBD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-37 amino acids from the Central region of human PCBD1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPCBD1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PCBD1
Synonyms DCOH, PCBD
Function Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity.
Cellular Location Cytoplasm. Nucleus. Note=Cytoplasmic and/or nuclear
Research Areas
Citations (0)

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PCBD1 encodes pterin-4 alpha-carbinolamine dehydratase, an enzyme involved in phenylalanine hydroxylation. A deficiency of this enzyme leads to hyperphenylalaninemia. The enzyme regulates the homodimerization of the transcription factor hepatocyte nuclear factor 1 (HNF1).


Schnetz-Boutaud,N.C.,, Genes Brain Behav. 8 (8), 753-757 (2009)
Clot,F.,, Brain 132 (PT 7), 1753-1763 (2009)

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Cat# AP9111c
(40 western blots)
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