|Application ||WB, E|
|Calculated MW||33548 Da|
|Antigen Region||85-113 aa|
|Other Names||Short-chain dehydrogenase/reductase 3, DD831, Retinal short-chain dehydrogenase/reductase 1, retSDR1, DHRS3|
|Target/Specificity||This DHRS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-113 amino acids from the Central region of human DHRS3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DHRS3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the reduction of all-trans-retinal to all- trans-retinol in the presence of NADPH.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed with highest levels found in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea and spinal cord. Lower levels found in skeletal muscle, intestine and lymph node. No expression detected in brain In the retina, expressed in cone but not rod outer segments|
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Provided below are standard protocols that you may find useful for product applications.
DHRS3 catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids.
Persson,B., et.al., Chem. Biol. Interact. 178 (1-3), 94-98 (2009)
Roni,V., et.al., BMC Genomics 8, 42 (2007)
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