|Application ||WB, FC, E|
|Calculated MW||27856 Da|
|Antigen Region||231-259 aa|
|Other Names||Claudin-18, CLDN18|
|Target/Specificity||This CLDN18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-259 amino acids of human CLDN18.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLDN18 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity.|
|Cellular Location||Cell junction, tight junction. Cell membrane; Multi-pass membrane protein|
|Tissue Location||Concentrated at the cell-cell borders of epithelial cells|
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Provided below are standard protocols that you may find useful for product applications.
CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells.
Sahin,U., et.al., Clin. Cancer Res. 14 (23), 7624-7634 (2008)
Zwiers,A., et.al, Inflamm. Bowel Dis. 14 (12), 1652-1659 (2008)
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