|Application ||WB, E|
|Calculated MW||37466 Da|
|Antigen Region||269-295 aa|
|Other Names||Exostosin-like 2, Alpha-1, 4-N-acetylhexosaminyltransferase EXTL2, Alpha-GalNAcT EXTL2, EXT-related protein 2, Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, Processed exostosin-like 2, EXTL2, EXTR2|
|Target/Specificity||This EXTL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 269-295 amino acids from the C-terminal region of human EXTL2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EXTL2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N- acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type II membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
EXTL2 is a glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains.
Kaidonis,X., et.al, Eur. J. Hum. Genet. 18 (2), 194-199 (2010)
Sobhany,M., et.al, J. Biol. Chem. 280 (25), 23441-23445 (2005)
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