|Application ||WB, IHC-P, E|
|Other Accession||Q62923, Q64387, O62647|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||20295 Da|
|Antigen Region||126-151 aa|
|Other Names||Prepronociceptin, Neuropeptide 1, Nociceptin, Orphanin FQ, PPNOC, Neuropeptide 2, PNOC, OFQ|
|Target/Specificity||This PNOC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-151 amino acids from the Central region of human PNOC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PNOC Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.|
|Tissue Location||Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation|
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Provided below are standard protocols that you may find useful for product applications.
PNOC is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. This protein may be involved in neuronal differentiation and development
Kuzmin,A., et.al., Brain Res. 1305 SUPPL, S80-S85 (2009)
Rocha,L., et.al., Neurobiol. Dis. 35 (3), 466-473 (2009)
de Krom,M., et.al., Biol. Psychiatry 65 (7), 625-630 (2009)
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