|Application ||WB, IHC-P, FC, E|
|Calculated MW||75207 Da|
|Antigen Region||89-117 aa|
|Other Names||Inositol-trisphosphate 3-kinase C, Inositol 1, 5-trisphosphate 3-kinase C, IP3 3-kinase C, IP3K C, InsP 3-kinase C, ITPKC, IP3KC|
|Target/Specificity||This ITPKC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-117 amino acids from the N-terminal region of human ITPKC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ITPKC Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate.|
|Cellular Location||Nucleus. Cytoplasm. Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity|
|Tissue Location||Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain|
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Provided below are standard protocols that you may find useful for product applications.
ITPKC encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease.
Chi,H. Hum. Mol. Genet. 19 (6), 1147-1151 (2010)
Onouchi,Y. Nat. Genet. 40 (1), 35-42 (2008)
Nalaskowski,M.M. Biol. Chem. 387 (5), 583-593 (2006)
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