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ITPKC Antibody (N-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP9326a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP9326a-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
ITPKC Antibody (N-term) - Product info | |
| Application | WB, IHC, FC
|
| Primary Accession | Q96DU7 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 75207 Da |
ITPKC Antibody (N-term) - Additional info | |
| Gene ID 80271 | |
| Other Names ITPKC; IP3KC; Inositol-trisphosphate 3-kinase C; Inositol 1, 4, 5-trisphosphate 3-kinase C | |
| Target/Specificity This ITPKC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96~125 amino acids from the N-terminal region of human ITPKC. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ITPKC Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ITPKC Antibody (N-term) - Protein Information | |
| Name ITPKC | |
| Synonyms IP3KC | |
| Function Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate (By similarity) | |
| Cellular Location Nucleus. Cytoplasm. Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity | |
| Tissue Location Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain | |
ITPKC Antibody (N-term) - Related products
AP9326a: ITPKC Antibody (N-term)
ITPKC Antibody (N-term) - Application data
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Western blot analysis of ITPKC Antibody (N-term) (Cat. #AP9326a) in HepG2 cell line lysates (35ug/lane). ITPKC (arrow) was detected using the purified Pab.
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Formalin-fixed and paraffin-embedded human skeletal muscle reacted with ITPKC Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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ITPKC Antibody (N-term) (Cat. #AP9326a) flow cytometric analysis of CEM cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
ITPKC Antibody (N-term) - Research Areas
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BACKGROUND
ITPKC encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease.
REFERENCES
Chi,H. Hum. Mol. Genet. 19 (6), 1147-1151 (2010) Onouchi,Y. Nat. Genet. 40 (1), 35-42 (2008) Nalaskowski,M.M. Biol. Chem. 387 (5), 583-593 (2006)
