|Application ||WB, IHC-P, FC, E|
|Calculated MW||69505 Da|
|Antigen Region||1-30 aa|
|Other Names||Eyes absent homolog 4, EYA4|
|Target/Specificity||This EYA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the C-terminal region of human EYA4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EYA4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity).|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Highly expressed in heart and skeletal muscle.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
EYA4 encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti.
Miller,S.J. Oncogene 29 (3), 368-379 (2010)
Li,H. J. Exp. Clin. Cancer Res. 28, 145 (2009)
Melzer,D. PLoS Genet. 4 (5), E1000072 (2008)
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