|Application ||WB, FC, E|
|Calculated MW||49631 Da|
|Antigen Region||218-246 aa|
|Other Names||Zinc transporter ZIP8, BCG-induced integral membrane protein in monocyte clone 103 protein, LIV-1 subfamily of ZIP zinc transporter 6, LZT-Hs6, Solute carrier family 39 member 8, Zrt- and Irt-like protein 8, ZIP-8, SLC39A8, BIGM103, ZIP8|
|Target/Specificity||This S39A8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-246 amino acids from the Central region of human S39A8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||S39A8 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a manganese and zinc influx transporter (PubMed:12504855, PubMed:26637978). Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake into the brain (PubMed:26637978).|
|Cellular Location||Membrane; Multi-pass membrane protein. Note=Associated with the lysosomal/endosomal compartment following transfection|
|Tissue Location||Expressed in thymus, placenta, lung, liver, pancreas and, to a lower extent, in spleen, testis, ovary, small intestine, colon, leukocyte, heart. Highest expression is observed in pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
S39A8 encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke.
Wang,L. Cancer Epidemiol. Biomarkers Prev. 17 (12), 3558-3566 (2008)
Aiba,I. Mol. Pharmacol. 74 (3), 823-833 (2008)
Besecker,B. Am. J. Physiol. Lung Cell Mol. Physiol. 294 (6), L1127-L1136 (2008)
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