|Application ||WB, IHC-P, FC, E|
|Other Accession||Q8R3S2, Q3SYV5|
|Calculated MW||31538 Da|
|Antigen Region||254-283 aa|
|Other Names||Tetraspanin-33, Tspan-33, Penumbra, hPen, Proerythroblast new membrane, TSPAN33, PEN|
|Target/Specificity||This TSPAN33 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 254-283 amino acids from the C-terminal region of human TSPAN33.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TSPAN33 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Predominantly expressed in erythroblasts.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
TSPAN33 plays an important role in normal erythropoiesis. It has a role in the differentiation of erythroid progenitors.
Heikens, M.J., et al. Blood 109(8):3244-3252(2007)
Huang, S., et al. Genomics 86(6):674-684(2005)
Chen, Z., et al. Cancer Genet. Cytogenet. 162(2):95-98(2005)
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