|Application ||WB, IHC-P, FC, E|
|Calculated MW||15258 Da|
|Antigen Region||100-128 aa|
|Other Names||Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain, HBA1|
|Target/Specificity||This HBA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-128 amino acids from the Central region of human HBA2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Precautions||HBA2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in oxygen transport from the lung to the various peripheral tissues.|
|Tissue Location||Red blood cells.|
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Provided below are standard protocols that you may find useful for product applications.
HBA2 located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported.
Sessa, R., et al. Am. J. Hematol. 85(2):143-144(2010)
Sharma, V., et al. Hematology 14(5):297-300(2009)
Waye, J.S., et al. Hemoglobin 33(6):519-522(2009)
Roy, P., et al. Hemoglobin 33(6):486-491(2009)
Joly, P., et al. Hemoglobin 33(3):196-205(2009)
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