ABHDB Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, WB, E |
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Primary Accession | Q8NFV4 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 33747 Da |
Antigen Region | 176-205 aa |
Gene ID | 83451 |
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Other Names | Alpha/beta hydrolase domain-containing protein 11, Abhydrolase domain-containing protein 11, 3---, Williams-Beuren syndrome chromosomal region 21 protein, ABHD11, WBSCR21 |
Target/Specificity | This ABHDB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-205 amino acids from the Central region of human ABHDB. |
Dilution | WB~~1:1000 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ABHDB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ABHD11 (HGNC:16407) |
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Synonyms | WBSCR21 |
Function | Catalyzes the hydrolysis of diacylglycerol in vitro and may function as a key regulator in lipid metabolism, namely by regulating the intracellular levels of diacylglycerol (PubMed:32579589). 1,2- diacyl-sn-glycerols are the preferred substrate over 1,3-diacyl-sn- glycerols (By similarity). The enzyme hydrolyzes stearate in preference to palmitate from the sn-1 position of 1,2-diacyl-sn-glycerols (By similarity). Maintains the functional lipoylation of the 2-oxoglutarate dehydrogenase complex (OGDHc) through its interaction with the OGDHc by preventing the formation of lipoyl adducts (PubMed:32792488). In addition, is also required for the expansion and differentiation of embryonic stem cells (ESCs) (By similarity). |
Cellular Location | Mitochondrion. Mitochondrion matrix |
Tissue Location | Ubiquitously expressed (PubMed:12073013). Highly expressed in small intestine, prostate and thyroid, while aorta and colon tissues exhibit weak expression levels (PubMed:32579589) |
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Provided below are standard protocols that you may find useful for product applications.
Background
ABHDB encodes a protein containing an alpha/beta hydrolase fold domain. This protein is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23.
References
Tsuritani, K., et al. Genome Res. 17(7):1005-1014(2007)
Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)
Merla, G., et al. Hum. Genet. 110(5):429-438(2002)
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