|Application ||WB, E|
|Other Accession||Q9QZH0, Q61088, Q9IA05|
|Predicted||Chicken, Mouse, Rat|
|Calculated MW||59881 Da|
|Antigen Region||495-522 aa|
|Other Names||Frizzled-4, Fz-4, hFz4, FzE4, CD344, FZD4|
|Target/Specificity||This FZD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 495-522 amino acids from the C-terminal region of human FZD4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Precautions||FZD4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.|
|Cellular Location||Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
|Tissue Location||Almost ubiquitous. Largely expressed in adult heart, skeletal muscle, ovary, and fetal kidney. Moderate amounts in adult liver, kidney, pancreas, spleen, and fetal lung, and small amounts in placenta, adult lung, prostate, testis, colon, fetal brain and liver|
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Provided below are standard protocols that you may find useful for product applications.
FZD4 may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway.
?Ells, A., et al. Ophthalmic Genet. 31(1):37-43(2010)
?Drenser, K.A., et al. Arch. Ophthalmol. 127(12):1649-1654(2009)
?Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
?Robitaille, J.M., et al. Ophthalmic Genet. 30(1):23-30(2009)
?Tickenbrock, L., et al. Int. J. Oncol. 33(6):1215-1221(2008)
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