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FZD4 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - FZD4 Antibody (C-term) AP9471b
    Western blot analysis of FZD4 Antibody (C-term) (Cat. #AP9471b) in 293 cell line lysates (35ug/lane).FZD4 (arrow) was detected using the purified Pab;
  • WB - FZD4 Antibody (C-term) AP9471b
    Western blot analysis of FZD4 Antibody (C-term) (Cat. #AP9471b) in mouse heart tissue lysates (35ug/lane). FZD4 (arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9ULV1
Other Accession Q9QZH0, Q61088, Q9IA05
Reactivity Human
Predicted Chicken, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 59881 Da
Antigen Region 495-522 aa
Additional Information
Gene ID 8322
Other Names Frizzled-4, Fz-4, hFz4, FzE4, CD344, FZD4
Target/Specificity This FZD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 495-522 amino acids from the C-terminal region of human FZD4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFZD4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FZD4
Function Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Cellular Location Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Tissue Location Almost ubiquitous. Largely expressed in adult heart, skeletal muscle, ovary, and fetal kidney. Moderate amounts in adult liver, kidney, pancreas, spleen, and fetal lung, and small amounts in placenta, adult lung, prostate, testis, colon, fetal brain and liver
Research Areas
Citations (0)

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FZD4 may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway.


?Ells, A., et al. Ophthalmic Genet. 31(1):37-43(2010)
?Drenser, K.A., et al. Arch. Ophthalmol. 127(12):1649-1654(2009)
?Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
?Robitaille, J.M., et al. Ophthalmic Genet. 30(1):23-30(2009)
?Tickenbrock, L., et al. Int. J. Oncol. 33(6):1215-1221(2008)

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$ 295.00
$ 99.00
Cat# AP9471b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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