|Application ||WB, E|
|Other Accession||Q8BMB0, Q7ZUV7|
|Calculated MW||141468 Da|
|Antigen Region||46-75 aa|
|Other Names||Protein EMSY, EMSY, C11orf30|
|Target/Specificity||This C11orf30 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-75 amino acids from the N-terminal region of human C11orf30.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||C11orf30 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors.|
|Cellular Location||Nucleus. Note=Localizes to DNA damage markers in irradiated cells, suggesting that it participates in DNA repair process|
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Provided below are standard protocols that you may find useful for product applications.
Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2.
?Esparza-Gordillo, J., et al. Nat. Genet. 41(5):596-601(2009)
?Garapaty, S., et al. J. Biol. Chem. 284(12):7542-7552(2009)
?Mavaddat, N., et al. Cancer Epidemiol. Biomarkers Prev. 18(1):255-259(2009)
?Vega, A., et al. Gynecol. Oncol. 112(1):210-214(2009)
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