|Application ||WB, E|
|Other Accession||Q8K1M7, Q499E0|
|Calculated MW||88445 Da|
|Antigen Region||40-68 aa|
|Other Names||BMP/retinoic acid-inducible neural-specific protein 3, DBCCR1-like protein 1, BRINP3, DBCCR1L, DBCCR1L1, FAM5C|
|Target/Specificity||This FAM5C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-68 amino acids from the N-terminal region of human FAM5C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FAM5C Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DBCCR1L, DBCCR1L1, FAM5C|
|Function||Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development.|
|Cellular Location||Secreted. Mitochondrion|
|Tissue Location||Strongly expressed in oral keratinocytes compared to the weak expression in tongue squamous cell carcinoma (SCC). Expressed in endothelial and aortic smooth muscle cells Overexpressed in gonadotropinomas compared to normal pituitarie tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Kuroiwa, T., et al. Oncol. Rep. 22(5):1005-1011(2009)
Connelly, J.J., et al. BMC Med. Genet. 9, 33 (2008)
Shorts-Cary, L., et al. Endocrinology 148(3):967-975(2007)
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