|Application ||WB, E|
|Calculated MW||45070 Da|
|Antigen Region||118-145 aa|
|Other Names||Isobutyryl-CoA dehydrogenase, mitochondrial, 1399-, Activator-recruited cofactor 42 kDa component, ARC42, Acyl-CoA dehydrogenase family member 8, ACAD-8, ACAD8, ARC42, IBD|
|Target/Specificity||This ACAD8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-145 amino acids from the Central region of human ACAD8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ACAD8 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has very high activity toward isobutyryl-CoA. Is an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Plays a role in transcriptional coactivation within the ARC complex.|
|Tissue Location||Detected at comparable levels in all tissues examined (heart, lung, brain, skeletal muscle, pancreas and placenta). Weakly expressed in liver and kidney|
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Provided below are standard protocols that you may find useful for product applications.
ACAD8 is a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. This protein is a mitochondrial enzyme that functions in catabolism of the branched-chain amino acid valine.
Wollmer, M.A., et al. Neurogenetics 8(3):179-188(2007)
Ma, J., et al. Atherosclerosis 191(1):63-72(2007)
Battaile, K.P., et al. J. Biol. Chem. 279(16):16526-16534(2004)
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