- CITATIONS: 2
|Application ||WB, E|
|Calculated MW||22988 Da|
|Antigen Region||1-30 aa|
|Other Names||DNA replication complex GINS protein PSF1, GINS complex subunit 1, GINS1, KIAA0186, PSF1|
|Target/Specificity||This GINS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GINS1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Precautions||GINS1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA. GINS1 is essential for function.|
Provided below are standard protocols that you may find useful for product applications.
The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1, Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]).
Nagahama, Y., et al. Cancer Res. 70(3):1215-1224(2010) Kamada, K., et al. Nat. Struct. Mol. Biol. 14(5):388-396(2007)
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