|Application ||WB, IHC-P, FC, E|
|Calculated MW||34516 Da|
|Antigen Region||89-118 aa|
|Other Names||Testosterone 17-beta-dehydrogenase 3, 17-beta-hydroxysteroid dehydrogenase type 3, 17-beta-HSD 3, Testicular 17-beta-hydroxysteroid dehydrogenase, HSD17B3, EDH17B3|
|Target/Specificity||This HSD17B3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-118 amino acids from the Central region of human HSD17B3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HSD17B3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH.|
|Cellular Location||Endoplasmic reticulum|
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Provided below are standard protocols that you may find useful for product applications.
This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia.
Li, J., et al. Breast Cancer Res. 12 (2), R19 (2010) :
Sata, F., et al. J Sex Med (2010) In press :
Ahn, J., et al. Hum. Mol. Genet. 18(19):3749-3757(2009)
Chakrabarti, B., et al. Autism Res 2(3):157-177(2009)
Beuten, J., et al. Cancer Epidemiol. Biomarkers Prev. 18(6):1869-1880(2009)
Andersson, S., et al. J. Clin. Endocrinol. Metab. 81(1):130-136(1996)
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