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FANCC Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP9522b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP9522b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
FANCC Antibody (C-term) - Product info | |
| Application | WB, IHC, FC, IF
|
| Primary Accession | Q00597 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 63429 Da |
FANCC Antibody (C-term) - Additional info | |
| Gene ID 2176 | |
| Other Names FANCC; FAC; FACC; Fanconi anemia group C protein | |
| Target/Specificity This FANCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 529~558 amino acids from the C-terminal region of human FANCC. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 FC~~1:10~50 IF~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions FANCC Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
FANCC Antibody (C-term) - Protein Information | |
| Name FANCC | |
| Synonyms FAC, FACC | |
| Function DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 | |
| Cellular Location Nucleus. Cytoplasm. Note=The major form is nuclear. The minor form is cytoplasmic | |
| Tissue Location Ubiquitous. | |
FANCC Antibody (C-term) - Related products
AP9522b: FANCC Antibody (C-term)
RI11934: FANCC predesign siRNA
DC04176: Human FANCC cDNA Clone
FANCC Antibody (C-term) - Application data
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FANCC Antibody (C-term) (Cat. #AP9522b) western blot analysis in HL-60,HepG2 cell line lysates (35ug/lane).This demonstrates the FANCC antibody detected the FANCC protein (arrow).
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FANCC Antibody (C-term)(Cat. #AP9522b) IHC analysis in formalin fixed and paraffin embedded testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the FANCC Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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FANCC Antibody (C-term) (Cat. #AP9522b) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Confocal immunofluorescent analysis of FANCC Antibody (C-term)(Cat. #AP9522b) with 293 cell followed by Alexa Fluor® 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
FANCC Antibody (C-term) - Research Areas
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BACKGROUND
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This protein is for complementation group C.
REFERENCES
Barroso, E., et al. Breast Cancer Res. Treat. 118(3):655-660(2009) McWilliams, R.R., et al. Cancer Epidemiol. Biomarkers Prev. 18(9):2549-2552(2009) Michiels, S., et al. Carcinogenesis 30(5):763-768(2009) Palmieri, R.T., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3567-3572(2008) Sinha, S., et al. Mol. Cancer 7, 84 (2008) :
