|Application ||WB, FC, E|
|Calculated MW||41823 Da|
|Antigen Region||252-278 aa|
|Other Names||Tumor necrosis factor receptor superfamily member 10D, Decoy receptor 2, DcR2, TNF-related apoptosis-inducing ligand receptor 4, TRAIL receptor 4, TRAIL-R4, TRAIL receptor with a truncated death domain, CD264, TNFRSF10D, DCR2, TRAILR4, TRUNDD|
|Target/Specificity||This TNFRSF10D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 252-278 amino acids from the Central region of human TNFRSF10D.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TNFRSF10D Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DCR2, TRAILR4, TRUNDD|
|Function||Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF- kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
TNFRSF is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis.
Davila, S., et al. Genes Immun. (2010) In press :
Pei, G.T., et al. Biochem. Biophys. Res. Commun. 391(2):1274-1279(2010)
Lucas, H., et al. J. Dent. Res. 89(1):29-33(2010)
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
Chen, B., et al. Spine 34 (19), E677-E681 (2009) :
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