|Application ||WB, E|
|Calculated MW||21445 Da|
|Antigen Region||52-79 aa|
|Other Names||TRAF-interacting protein with FHA domain-containing protein A, Putative MAPK-activating protein PM14, Putative NF-kappa-B-activating protein 20, TRAF2-binding protein, TIFA, T2BP|
|Target/Specificity||This TIFA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-79 amino acids from the N-terminal region of human TIFA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TIFA Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism.|
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Provided below are standard protocols that you may find useful for product applications.
Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism.
?Minoda, Y., et al. Biochem. Biophys. Res. Commun. 344(3):1023-1030(2006)
?Ea, C.K., et al. Proc. Natl. Acad. Sci. U.S.A. 101(43):15318-15323(2004)
?Matsuda, A., et al. Oncogene 22(21):3307-3318(2003)
?Takatsuna, H., et al. J. Biol. Chem. 278(14):12144-12150(2003)
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