|Application ||WB, E|
|Calculated MW||17136 Da|
|Antigen Region||91-120 aa|
|Other Names||Heat shock protein beta-6, HspB6, Heat shock 20 kDa-like protein p20, HSPB6|
|Target/Specificity||This HSPB6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91-120 amino acids from the Central region of human HSPB6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HSPB6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity.|
|Cellular Location||Cytoplasm. Nucleus. Secreted. Note=Translocates to nuclear foci during heat shock.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
HSPB6 is associated with actin (see MIM 102540) and modulates smooth muscle relaxation (Tessier et al., 2003 [PubMed 12842460]).
Fuchs, M., et al. Biochem. J. 425(1):245-255(2010)
Qian, J., et al. Circ. Res. 105(12):1223-1231(2009)
Bagneris, C., et al. J. Mol. Biol. 392(5):1242-1252(2009)
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