|Application ||WB, E|
|Calculated MW||91197 Da|
|Antigen Region||806-835 aa|
|Other Names||B-cell lymphoma/leukemia 11A, BCL-11A, B-cell CLL/lymphoma 11A, COUP-TF-interacting protein 1, Ecotropic viral integration site 9 protein homolog, EVI-9, Zinc finger protein 856, BCL11A, CTIP1, EVI9, KIAA1809, ZNF856|
|Target/Specificity||This BCL11A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 806-835 amino acids from the C-terminal region of human BCL11A.|
|Precautions||BCL11A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CTIP1, EVI9, KIAA1809, ZNF856|
|Function||Transcription factor associated with the BAF SWI/SNF chromatin remodeling complex (By similarity). Repressor of fetal hemoglobin (HbF) level (PubMed:26375765). Involved in brain development (PubMed:27453576). Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. Essential factor in lymphopoiesis required for B- cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1 (By similarity).|
|Cellular Location||Cytoplasm. Nucleus. Note=Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles (By similarity). Isoform 3: Cytoplasm. Nucleus. Note=Predominantly localized in the cytoplasm in the absence of interaction with isoform 1 and isoform 2. In presence of isoform 1 or isoform 2, translocates from the cytoplasm into nuclear paraspeckles|
|Tissue Location||Expressed at high levels in brain, spleen thymus, bone marrow and testis. Expressed in CD34-positive myeloid precursor cells, B-cells, monocytes and megakaryocytes. Expression is tightly regulated during B-cell development|
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Provided below are standard protocols that you may find useful for product applications.
BCL11A is a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6.
Solovieff, N., et al. Blood 115(9):1815-1822(2010)
Nuinoon, M., et al. Hum. Genet. 127(3):303-314(2010)
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