- CITATIONS: 1
|Application ||WB, E|
|Calculated MW||155985 Da|
|Antigen Region||943-972 aa|
|Other Names||Rab3 GTPase-activating protein non-catalytic subunit, RGAP-iso, Rab3 GTPase-activating protein 150 kDa subunit, Rab3-GAP p150, Rab3-GAP150, Rab3-GAP regulatory subunit, RAB3GAP2, KIAA0839|
|Target/Specificity||This RAB3GAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 943-972 amino acids from the C-terminal region of human RAB3GAP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RAB3GAP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters.|
|Cellular Location||Cytoplasm. Note=In neurons, it is enriched in the synaptic soluble fraction|
Provided below are standard protocols that you may find useful for product applications.
RAB3GAP2 belongs to the RAB3 protein family, members of which are involved in regulated exocytosis of neurotransmitters and hormones. This protein forms the Rab3 GTPase-activating complex with RAB3GAP1, where it constitutes the regulatory subunit, whereas the latter functions as the catalytic subunit. This gene has the highest level of expression in the brain, consistent with it having a key role in neurodevelopment.
Niwa, S., et al. Nat. Cell Biol. 10(11):1269-1279(2008)
Ng, E.L., et al. Brain Res Rev 58(1):236-246(2008)
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