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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CYTH3 Antibody (C-term)   

CYTH3 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CYTH3 Antibody (C-term) AP9673B
    Western blot analysis of CYTH3 Antibody (C-term) (Cat. #AP9673b) in Hela cell line lysates (35ug/lane). CYTH3 (arrow) was detected using the purified Pab;
  • WB - CYTH3 Antibody (C-term) AP9673B
    Western blot analysis of CYTH3 Antibody (C-term) (Cat. #AP9673b) in mouse cerebellum tissue lysates (35ug/lane). CYTH3 (arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43739
Other Accession P97696, O08967
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 46349 Da
Antigen Region 371-400 aa
Additional Information
Gene ID 9265
Other Names Cytohesin-3, ARF nucleotide-binding site opener 3, Protein ARNO3, General receptor of phosphoinositides 1, Grp1, PH, SEC7 and coiled-coil domain-containing protein 3, CYTH3, ARNO3, GRP1, PSCD3
Target/Specificity This CYTH3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 371-400 amino acids from the C-terminal region of human CYTH3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCYTH3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CYTH3
Synonyms ARNO3, GRP1, PSCD3
Function Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP.
Cellular Location Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Note=Translocates from the cytosol to membranes enriched in phosphatidylinositol 3,4,5-trisphosphate
Tissue Location Almost absent from liver, thymus and peripheral blood lymphocytes
Research Areas
Citations (0)

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This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1.


Morishige, M., et al. Nat. Cell Biol. 10(1):85-92(2008)
Poirier, M.B., et al. Mol. Endocrinol. 19(8):1991-2005(2005)
Nevrivy, D.J., et al. J. Biol. Chem. 275(22):16827-16836(2000)
Ogasawara, M., et al. J. Biol. Chem. 275(5):3221-3230(2000)

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Cat# AP9673B
(40 western blots)
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