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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > CBAA1 Antibody (N-term)
CBAA1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BPX6 |
| Other Accession | Q4R518 |
| Reactivity | Human |
| Predicted | Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 54351 Da |
| Antigen Region | 52-81 aa |
| Gene ID | 10367 |
|---|---|
| Other Names | Calcium uptake protein 1, mitochondrial, Atopy-related autoantigen CALC, ara CALC, Calcium-binding atopy-related autoantigen 1, Hom s 4, MICU1, CALC, CBARA1 |
| Target/Specificity | This CBAA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-81 amino acids from the N-terminal region of human CBAA1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CBAA1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MICU1 |
|---|---|
| Synonyms | CALC {ECO:0000303|PubMed:16002733}, CBAR |
| Function | Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose- dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1- mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733). |
| Cellular Location | Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion intermembrane space |
| Tissue Location | Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Bordicchia, M., et al. Metab. Clin. Exp. (2009) In press :
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Natter, S., et al. FASEB J. 12(14):1559-1569(1998)
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$ 365.00
$ 140.00
Cat# AP9682a
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