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> home > Products > Antibodies > Biological Process > Cell Differentiation > AF5q31 Antibody (N-term)
AF5q31 Antibody (N-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP9688a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP9688a-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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AF5q31 Antibody (N-term) - Product info | |
| Application | WB
|
| Primary Accession | Q9UHB7 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 127459 Da |
AF5q31 Antibody (N-term) - Additional info | |
| Gene ID 27125 | |
| Other Names AFF4; AF5Q31; MCEF; AF4/FMR2 family member 4; ALL1-fused gene from chromosome 5q31 protein; Major CDK9 elongation factor-associated protein | |
| Target/Specificity This AF5q31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1~30 amino acids from the N-terminal region of human AF5q31. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions AF5q31 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
AF5q31 Antibody (N-term) - Protein Information | |
| Name AFF4 | |
| Synonyms AF5Q31, MCEF | |
| Function Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression | |
| Cellular Location Nucleus. | |
| Tissue Location Ubiquitously expressed. Strongly expressed in heart, placenta, skeletal muscle, pancreas and to a lower extent in brain | |
AF5q31 Antibody (N-term) - Related products
AP9688a: AF5q31 Antibody (N-term)
DC05497: Human AFF4 cDNA Clone
AF5q31 Antibody (N-term) - Application data
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Western blot analysis of AF5q31 Antibody (N-term) (Cat. #AP9688a) in HL-60 cell line lysates (35ug/lane). AF5q31 (arrow) was detected using the purified Pab.
AF5q31 Antibody (N-term) - Research Areas
AntibodiesBiological ProcessCell DifferentiationMetabolic ProcessPrimary Metabolic ProcessCellular Metabolic ProcessCellular ProcessMacromolecule Metabolic ProcessDevelopmental ProcessCellular Macromolecule Metabolic ProcessReproductive Developmental ProcessRegulation Of Metabolic ProcessCellular Developmental ProcessCell DevelopmentRegulation Of Cellular Metabolic ProcessBiological RegulationRegulation Of Macromolecule Metabolic ProcessRegulation Of Primary Metabolic ProcessRegulation Of Biological ProcessBiosynthetic ProcessReproductionMulticellular Organismal ProcessReproductive ProcessCellular Biosynthetic ProcessRegulation Of Cellular ProcessNitrogen Compound Metabolic ProcessCellular Nitrogen Compound Metabolic ProcessRNA Metabolic ProcessTranscription
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REFERENCES
Lin, C., et al. Mol. Cell 37(3):429-437(2010) Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007) Matsuoka, S., et al. Science 316(5828):1160-1166(2007) Niedzielski, M.F., et al. Int. J. Biol. Sci. 3(4):225-236(2007) Olsen, J.V., et al. Cell 127(3):635-648(2006) Olsen, J.V., et al. Cell 127(3):635-648(2006) Estable, M.C., et al. J. Biomed. Sci. 9(3):234-245(2002)
