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NEIL1 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - NEIL1 Antibody (Center) AP9696c
    Western blot analysis of NEIL1 Antibody (Center) (Cat. #AP9696c) in A2058 cell line lysates (35ug/lane). NEIL1 (arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96FI4
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 43684 Da
Antigen Region 130-159 aa
Additional Information
Gene ID 79661
Other Names Endonuclease 8-like 1, 322-, DNA glycosylase/AP lyase Neil1, DNA-(apurinic or apyrimidinic site) lyase Neil1, Endonuclease VIII-like 1, FPG1, Nei homolog 1, NEH1, Nei-like protein 1, NEIL1
Target/Specificity This NEIL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-159 amino acids from the Central region of human NEIL1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNEIL1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NEIL1
Function Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8- oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5- hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus. Chromosome. Note=During mitosis, associates with centrosomes and condensed chromatin
Tissue Location Ubiquitous..
Citations (0)

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NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).


Zhao, X., et al. Biochemistry 49(8):1658-1666(2010)
Forsbring, M., et al. Carcinogenesis 30(7):1147-1154(2009)
Couve, S., et al. J. Biol. Chem. 284(18):11963-11970(2009)
Muftuoglu, M., et al. J. Biol. Chem. 284(14):9270-9279(2009)
Horikawa, Y., et al. Clin. Cancer Res. 14(23):7956-7962(2008)

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$ 295.00
$ 99.00
Cat# AP9696c
(40 western blots)
Availability: In Stock
Bulk Size
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