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>   home   >   Products   >   Primary Antibodies   >   Developmental Biology   >   INSC Antibody (C-term)   

INSC Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - INSC Antibody (C-term) AP9702B
    INSC Antibody (C-term) (Cat. #AP9702b) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the INSC antibody detected the INSC protein (arrow).
  • IHC-P - INSC Antibody (C-term) AP9702B
    INSC antibody (C-term) (Cat. #AP9702b) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the INSC antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q1MX18
Other Accession NP_001027024.3, NP_001036001.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 63469 Da
Antigen Region 409-437 aa
Additional Information
Gene ID 387755
Other Names Protein inscuteable homolog, INSC
Target/Specificity This INSC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 409-437 amino acids from the C-terminal region of human INSC.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsINSC Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name INSC
Function May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex (PubMed:16458856). Involved in spindle orientation during mitosis. May regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (By similarity).
Cellular Location Cytoplasm. Cytoplasm, cell cortex Note=Uniformly distributed in the cytoplasm during interphase During metaphase, detected in the cell cortex, adjacent to the mitotic spindle poles.
Tissue Location Isoform 1 is expressed in various tissues with stronger expression in liver, kidney and small intestine. Isoform 2 is abundantly expressed in small intestine and to a lower extent in lung and pancreas.
Research Areas
Citations (0)

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Background

In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Vural, A., et al. Mol. Cell. Biol. 30(6):1528-1540(2010)
Rivadeneira, F., et al. Nat. Genet. 41(11):1199-1206(2009)
Izaki, T., et al. Biochem. Biophys. Res. Commun. 341(4):1001-1006(2006)
Katoh, M., et al. Int. J. Mol. Med. 11(1):111-116(2003)

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Cat# AP9702B
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(40 western blots)
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