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ADH7 Antibody (C-Term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP9703b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP9703b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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- Citiations : 0
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ADH7 Antibody (C-Term) - Product info | |
| Application | WB, IHC, FC, IF
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| Primary Accession | P40394 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 41481 Da |
ADH7 Antibody (C-Term) - Additional info | |
| Gene ID 131 | |
| Other Names ADH7; Alcohol dehydrogenase class 4 mu/sigma chain; Alcohol dehydrogenase class IV mu/sigma chain; Gastric alcohol dehydrogenase; Retinol dehydrogenase | |
| Target/Specificity This ADH7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 325~354 amino acids from the C-terminal region of human ADH7 Antibody (C-Term). | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 FC~~1:10~50 IF~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ADH7 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ADH7 Antibody (C-Term) - Protein Information | |
| Name ADH7 | |
| Function Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism | |
| Cellular Location Cytoplasm. | |
| Tissue Location Preferentially expressed in stomach. | |
ADH7 Antibody (C-Term) - Related products
AP9703b: ADH7 Antibody (C-Term)
DC14734: Human ADH7 cDNA Clone
ADH7 Antibody (C-Term) - Application data
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ADH7 Antibody (C-Term) (Cat. #AP9703b) western blot analysis in Jurkat,CEM,NCI-H460,K562,MDA-MB435 cell line lysates (35ug/lane).This demonstrates the ADH7 antibody detected the ADH7 protein (arrow).
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ADH7 Antibody (C-Term) (Cat. #AP9703b) IHC analysis in formalin fixed and paraffin embedded lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ADH7 Antibody (C-Term) for immunohistochemistry. Clinical relevance has not been evaluated.
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ADH7 Antibody (C-Term) (Cat. #AP9703b) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Confocal immunofluorescent analysis of ADH7 Antibody (C-Term) (Cat. #AP9703b) with NCI-H460 cell followed by Alexa Fluor® 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
ADH7 Antibody (C-Term) - Research Areas
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BACKGROUND
This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members.
REFERENCES
Kedishvili, N.Y., et al. J. Biol. Chem. 270(8):3625-3630(1995) Cheung, B., et al. Alcohol. Clin. Exp. Res. 19(1):185-186(1995) Farres, J., et al. Eur. J. Biochem. 224(2):549-557(1994) Pares, X., et al. FEBS Lett. 303(1):69-72(1992)
