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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SGMS2 Antibody (C-term)   

SGMS2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SGMS2 Antibody (C-term) AP9740b
    Western blot analysis of SGMS2 Antibody (C-term) (Cat. #AP9740b) in HepG2 cell line lysates (35ug/lane). SGMS2 (arrow) was detected using the purified Pab.
  • WB - SGMS2 Antibody (C-term) AP9740b
    Western blot analysis of SGMS2 Antibody (C-term) (Cat. #AP9740b) in mouse spleen tissue lysates (35ug/lane). SGMS2 (arrow) was detected using the purified Pab.
  • WB - SGMS2 Antibody (C-term) AP9740b
    Western blot analysis of SGMS2 (arrow) using rabbit polyclonal SGMS2 Antibody (C-term) (Cat. #AP9740b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SGMS2 gene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8NHU3
Other Accession Q4JM44, Q9D4B1, Q4R763
Reactivity Human, Mouse
Predicted Monkey, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 42280 Da
Antigen Region 338-365 aa
Additional Information
Gene ID 166929
Other Names Phosphatidylcholine:ceramide cholinephosphotransferase 2, Sphingomyelin synthase 2, SGMS2, SMS2
Target/Specificity This SGMS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 338-365 amino acids from the C-terminal region of human SGMS2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSGMS2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SGMS2
Synonyms SMS2
Function Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signal transduction and apoptosis. Regulation of sphingomyelin (SM) levels at the cell surface affects insulin sensitivity.
Cellular Location Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein Note=Predominantly plasma membrane, some in Golgi apparatus. Some localization in the perinuclear region where it colocalizes with a sialyltransferase
Tissue Location Brain, heart, kidney, liver, muscle and stomach. Also expressed in a number of cell lines such as carcinoma HeLa cells, hepatoma Hep-G2 cells, and colon carcinoma Caco-2 cells.
Research Areas
Citations (0)

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Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. SGMS2 is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. This protein is required for cell growth.


Ternes, P., et al. J. Lipid Res. 50(11):2270-2277(2009)
Liu, J., et al. Arterioscler. Thromb. Vasc. Biol. 29(6):850-856(2009)
Tani, M., et al. Biochem. Biophys. Res. Commun. 381(3):328-332(2009)

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$ 295.00
$ 99.00
Cat# AP9740b
(40 western blots)
Availability: In Stock
Bulk Size
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