|Application ||WB, IHC-P, E|
|Other Accession||Q6AXZ3, Q9JK24, Q5E9G1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||53316 Da|
|Antigen Region||50-79 aa|
|Other Names||Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma, Protein phosphatase subunit G5PR, Rhabdomyosarcoma antigen MU-RMS-406A/6C, PPP2R3C, C14orf10, G5PR|
|Target/Specificity||This P2R3C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-79 amino acids from the N-terminal region of human P2R3C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||P2R3C Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells.|
|Cellular Location||Nucleus. Cytoplasm. Note=Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis.|
|Tissue Location||Ubiquitously expressed in brain and other tissues.|
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Provided below are standard protocols that you may find useful for product applications.
P2R3C may regulate MCM3AP phosphorylation through phosphatase recruitment. It may play a role in the activation-induced cell death of B-cells (By similarity).
Xing, Y., et al. J. Exp. Med. 202(5):707-719(2005)
Kamnasaran, D., et al. Genomics 85(5):608-621(2005)
Kono, Y., et al. Genes Cells 7(8):821-834(2002)
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