|Application ||WB, E|
|Calculated MW||21396 Da|
|Antigen Region||16-45 aa|
|Other Names||Transmembrane 4 L6 family member 4, Intestine and liver tetraspan membrane protein, IL-TMP, TM4SF4, ILTMP|
|Target/Specificity||This T4S4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-45 amino acids from the N-terminal region of human T4S4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||T4S4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Jejunum and liver.|
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Provided below are standard protocols that you may find useful for product applications.
T4S4 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation. The use of alternate polyadenylation sites has been found for this gene.
Qiao, J., et al. Reprod. Biomed. Online 17(3):425-435(2008)
Berditchevski, F. J. Cell. Sci. 114 (PT 23), 4143-4151 (2001)
Wright, M.D., et al. Protein Sci. 9(8):1594-1600(2000)
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