|Application ||WB, IHC-P, FC, E|
|Calculated MW||168229 Da|
|Antigen Region||1049-1079 aa|
|Other Names||Pleckstrin homology domain-containing family H member 2, PLEKHH2, KIAA2028|
|Target/Specificity||This PKHH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1049-1079 amino acids from the C-terminal region of human PKHH2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PKHH2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Note=Localizes to foot process of podocytes. Localization to peripheral regions of lamellipodia seems to be dependent on PI3K|
|Tissue Location||Kidney. Reduced expression in patients with focal segmental glomerulosclerosis.|
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Provided below are standard protocols that you may find useful for product applications.
Greene, C.N., et al. Hum. Genet. 124(3):255-262(2008)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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