|Application ||WB, IHC-P, E|
|Calculated MW||46538 Da|
|Antigen Region||56-84 aa|
|Other Names||Methylmalonic aciduria type A protein, mitochondrial, 36--, MMAA|
|Target/Specificity||This MMAA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-84 amino acids from the N-terminal region of human MMAA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MMAA Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GTPase, binds and hydrolyzes GTP (PubMed:28497574, PubMed:20876572). Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis. Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MUT) and reactivation of the enzyme during catalysis (PubMed:28497574, PubMed:20876572).|
|Tissue Location||Widely expressed. Highest expression is observed in liver and skeletal muscle|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is involved in the translocation of cobalamin into the mitochondrion, where it is used in the final steps of adenosylcobalamin synthesis. Adenosylcobalamin is a coenzyme required for the activity of methylmalonyl-CoA mutase. Defects in this gene are a cause of methylmalonic aciduria.
Honjo, R.S., et al. Genet Test Mol Biomarkers 13(2):181-183(2009)
Merinero, B., et al. J. Inherit. Metab. Dis. 31(1):55-66(2008)
Horster, F., et al. Pediatr. Res. 62(2):225-230(2007)
Padovani, D., et al. J. Biol. Chem. 281(26):17838-17844(2006)
Lerner-Ellis, J.P., et al. Hum. Mutat. 24(6):509-516(2004)
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