|Application ||WB, IHC-P, E|
|Calculated MW||32936 Da|
|Antigen Region||81-110 aa|
|Other Names||Estradiol 17-beta-dehydrogenase 11, 17-beta-hydroxysteroid dehydrogenase 11, 17-beta-HSD 11, 17bHSD11, 17betaHSD11, 17-beta-hydroxysteroid dehydrogenase XI, 17-beta-HSD XI, 17betaHSDXI, Cutaneous T-cell lymphoma-associated antigen HD-CL-03, CTCL-associated antigen HD-CL-03, Dehydrogenase/reductase SDR family member 8, Retinal short-chain dehydrogenase/reductase 2, retSDR2, HSD17B11, DHRS8, PAN1B|
|Target/Specificity||This HSD17B11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-110 amino acids from the N-terminal region of human HSD17B11.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HSD17B11 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DHRS8, PAN1B, SDR16C2|
|Function||Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor- associated antigen in cutaneous T-cell lymphoma.|
|Tissue Location||Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in bronchioles, but not in alveoli. In the eye, it is detected in the nonpigmented epithelium of the ciliary body and, at lower level, in the inner nuclear layer of the retina (at protein level). Widely expressed. Highly expressed in retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart.|
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Provided below are standard protocols that you may find useful for product applications.
Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones.
Persson, B., et al. Chem. Biol. Interact. 178 (1-3), 94-98 (2009)
Nakamura, Y., et al. Neoplasma 56(4):317-320(2009)
Horiguchi, Y., et al. Arch. Biochem. Biophys. 479(2):121-130(2008)
Hartmann, T.B., et al. Br. J. Dermatol. 150(2):252-258(2004)
Chai, Z., et al. Endocrinology 144(5):2084-2091(2003)
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