|Application ||WB, IHC-P, FC, E|
|Other Accession||P32851, O35526|
|Calculated MW||33023 Da|
|Antigen Region||29-57 aa|
|Other Names||Syntaxin-1A, Neuron-specific antigen HPC-1, STX1A, STX1|
|Target/Specificity||This STX1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-57 amino acids from the N-terminal region of human STX1A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||STX1A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome|
|Tissue Location||Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis.
Yoshida, T., et al. Int. J. Mol. Med. 24(2):233-246(2009)
Hamdan, F.F., et al. Ann. Neurol. 65(6):748-753(2009)
Corominas, R., et al. Neurosci. Lett. 455(2):105-109(2009)
Chen, C.S., et al. J. Biol. Chem. 284(11):6877-6884(2009)
Ramakrishnan, N.A., et al. J. Biol. Chem. 284(3):1364-1372(2009)
Tian, J.H., et al. J. Biol. Chem. 278(28):26265-26274(2003)
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