|Application ||WB, IHC-P, E|
|Calculated MW||35197 Da|
|Antigen Region||292-320 aa|
|Other Names||Barttin, BSND, BART|
|Target/Specificity||This BSND antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 292-320 amino acids from the C-terminal region of human BSND.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BSND Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=A significant amount also observed intracellularly. Staining in membranes of the renal tubule and of potassium-secreting epithelia of the inner ear is basolateral (By similarity).|
|Tissue Location||Expressed primarily in kidney. Expressed in specific nephron segments and in the stria vascularis of the inner ear.|
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Provided below are standard protocols that you may find useful for product applications.
BSND encodes an essential beta subunit for CLC chloride channels. These heteromeric channels localize to basolateral membranes of renal tubules and of potassium-secreting epithelia of the inner ear.
Riazuddin, S., et al. Am. J. Hum. Genet. 85(2):273-280(2009)
Brochard, K., et al. Nephrol. Dial. Transplant. 24(5):1455-1464(2009)
Bircan, Z., et al. Pediatr. Nephrol. 24(4):841-844(2009)
Kathiresan, S., et al. Nat. Genet. 41(3):334-341(2009)
Kathiresan, S., et al. Nat. Genet. 41(1):56-65(2009)
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