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MAP4K3 Antibody
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, FC, IHC-P, E |
|---|---|
| Primary Accession | Q8IVH8 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 101316 Da |
| Gene ID | 8491 |
|---|---|
| Other Names | Mitogen-activated protein kinase kinase kinase kinase 3, Germinal center kinase-related protein kinase, GLK, MAPK/ERK kinase kinase kinase 3, MEK kinase kinase 3, MEKKK 3, MAP4K3, RAB8IPL1 |
| Target/Specificity | This MAP4K3 antibody is generated from rabbits immunized with a recombinant protein of human MAP4K3. |
| Dilution | WB~~1:1000 FC~~1:10~50 IHC-P~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MAP4K3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MAP4K3 (HGNC:6865) |
|---|---|
| Synonyms | RAB8IPL1 |
| Function | Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (PubMed:9275185). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). |
| Tissue Location | Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver |
Research Areas
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$ 385.00
Cat# AP9860A
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