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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MAP4K3 Antibody   

MAP4K3 Antibody

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - MAP4K3 Antibody AP9860A
    Western blot analysis of MAP4K3 Antibody (Cat. #AP9860a) in HepG2 cell line lysates (35ug/lane). MAP4K3 (arrow) was detected using the purified Pab.
  • IHC-P - MAP4K3 Antibody AP9860A
    MAP4K3 Antibody (Cat. #AP9860a) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MAP4K3 Antibody for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - MAP4K3 Antibody AP9860A
    MAP4K3 Antibody (Cat. #AP9860a) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8IVH8
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 101316 Da
Additional Information
Gene ID 8491
Other Names Mitogen-activated protein kinase kinase kinase kinase 3, Germinal center kinase-related protein kinase, GLK, MAPK/ERK kinase kinase kinase 3, MEK kinase kinase 3, MEKKK 3, MAP4K3, RAB8IPL1
Target/Specificity This MAP4K3 antibody is generated from rabbits immunized with a recombinant protein of human MAP4K3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMAP4K3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP4K3
Synonyms RAB8IPL1
Function May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
Tissue Location Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver
Research Areas
Citations (0)

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MAP4K3 encodes a member of the Ste20 family of serine/threonine protein kinases. The protein belongs to the subfamily that consists of members, such as germinal center kinase (GCK), that are characterized by an N-terminal catalytic domain and C-terminal regulatory domain. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase kinase 1 (MEKK1). This gene previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3).


Yan, L., et al. Mol. Cell 37(5):633-642(2010)
Ichikawa, S., et al. J. Bone Miner. Res. (2010) In press :
Lam, D., et al. Proc. Natl. Acad. Sci. U.S.A. 106(29):11978-11983(2009)
Wu, C., et al. Proteomics 7(11):1775-1785(2007)

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Cat# AP9860A
(40 western blots)
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