|Application ||WB, FC, E|
|Other Accession||P26770, Q91WF3|
|Calculated MW||119794 Da|
|Antigen Region||415-441 aa|
|Other Names||Adenylate cyclase type 4, ATP pyrophosphate-lyase 4, Adenylate cyclase type IV, Adenylyl cyclase 4, ADCY4|
|Target/Specificity||This ADCY4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 415-441 amino acids from the Central region of human ADCY4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ADCY4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cytoplasm|
|Tissue Location||Detected in the zona glomerulosa and the zona fasciculata in the adrenal gland (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals.
Rhim, J.H., et al. Aging Cell 5(6):451-461(2006)
Jiang, G., et al. Am. J. Physiol. Endocrinol. Metab. 284 (4), E671-E678 (2003)
Sunahara, R.K., et al. Mol. Interv. 2(3):168-184(2002)
Ludwig, M.G., et al. J. Recept. Signal Transduct. Res. 22 (1-4), 79-110 (2002)
Cote, M., et al. J. Clin. Endocrinol. Metab. 86(9):4495-4503(2001)
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