|Application ||WB, FC, IF, E|
|Calculated MW||38954 Da|
|Antigen Region||4-32 aa|
|Other Names||Interferon-inducible protein AIM2, Absent in melanoma 2, AIM2|
|Target/Specificity||This AIM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-32 amino acids from the N-terminal region of human AIM2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AIM2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.|
|Cellular Location||Nucleus. Cytoplasm. Note=Activated inflammasomes can aggregate in the cytosol as speck-like particles|
|Tissue Location||Expressed in spleen, small intestine, peripheral blood leukocytes, and testis|
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Provided below are standard protocols that you may find useful for product applications.
AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.
Patsos, G., et al. Int. J. Cancer 126(8):1838-1849(2010)
Patsos, G., et al. Glycobiology 19(7):726-734(2009)
Fernandes-Alnemri, T., et al. Nature 458(7237):509-513(2009)
Hornung, V., et al. Nature 458(7237):514-518(2009)
Woerner, S.M., et al. Genes Chromosomes Cancer 46(12):1080-1089(2007)
Cresswell, K.S., et al. Biochem. Biophys. Res. Commun. 326(2):417-424(2005)
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