|Application ||WB, FC, IF, E|
|Calculated MW||38954 Da|
|Antigen Region||4-32 aa|
|Other Names||Interferon-inducible protein AIM2, Absent in melanoma 2, AIM2|
|Target/Specificity||This AIM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-32 amino acids from the N-terminal region of human AIM2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AIM2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.|
|Cellular Location||Nucleus. Cytoplasm. Note=Activated inflammasomes can aggregate in the cytosol as speck-like particles|
|Tissue Location||Expressed in spleen, small intestine, peripheral blood leukocytes, and testis|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.
Patsos, G., et al. Int. J. Cancer 126(8):1838-1849(2010)
Patsos, G., et al. Glycobiology 19(7):726-734(2009)
Fernandes-Alnemri, T., et al. Nature 458(7237):509-513(2009)
Hornung, V., et al. Nature 458(7237):514-518(2009)
Woerner, S.M., et al. Genes Chromosomes Cancer 46(12):1080-1089(2007)
Cresswell, K.S., et al. Biochem. Biophys. Res. Commun. 326(2):417-424(2005)
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