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FOXK1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - FOXK1 Antibody (C-term) AP9880b
    Anti-FOXK1Antibody(C-term) at 1:500 dilution + K562 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 75 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • FC - FOXK1 Antibody (C-term) AP9880b
    FOXK1 Antibody (C-term) (Cat. #AP9880b) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession P85037
Other Accession P42128
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 75457 Da
Antigen Region 684-710 aa
Additional Information
Gene ID 221937
Other Names Forkhead box protein K1, Myocyte nuclear factor, MNF, FOXK1 {ECO:0000303|PubMed:15202027, ECO:0000303|PubMed:15289879}
Target/Specificity This FOXK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 684-710 amino acids from the C-terminal region of human FOXK1.
Dilution WB~~1:500
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFOXK1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOXK1 {ECO:0000303|PubMed:15202027, ECO:0000303|PubMed:15289879}
Function Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Important regulatory factor of the myogenic progenitor cell population. Involved in the cell cycle process, promotes proliferation by repressing Foxo4 transcriptional activity and the cyclin-dependent kinase inhibitor, p21CIP, in the myogenic progenitor cells. Represses myogenic differentiation by inhibiting MEFC acitivity. Has a role in remodeling processes of adult muscles that occur in response to physiological stimuli. Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136).
Cellular Location Nucleus {ECO:0000255, ECO:0000269|PubMed:23186163}
Tissue Location Expressed both developing and adult tissues. In adults, significant expression is seen in tumors of the brain, colon and lymph node.
Research Areas
Citations (0)

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Background

FOXK1 is a transcriptional activator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. It plays a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli.

References

Olsen, J.V., et al. Cell 127(3):635-648(2006)
Tsai, K.L., et al. J. Biol. Chem. 281(25):17400-17409(2006)
Huang, J.T., et al. Int. J. Oncol. 25(3):751-757(2004)
Katoh, M., et al. Int. J. Mol. Med. 14(1):127-132(2004)

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$ 295.00
$ 99.00
Cat# AP9880b
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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