|Application ||WB, IHC-P, E|
|Other Accession||Q5F339, A5PJG7|
|Calculated MW||30602 Da|
|Antigen Region||173-200 aa|
|Other Names||Cytochrome c-type heme lyase, CCHL, Holocytochrome c-type synthase, HCCS, CCHL|
|Target/Specificity||This HCCS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 173-200 amino acids from the Central region of human HCCS.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HCCS Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Links covalently the heme group to the apoprotein of cytochrome c.|
|Cellular Location||Mitochondrion inner membrane.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is an enzyme that covalently links a heme group to the apoprotein of cytochrome c. Defects in this gene are a cause of microphthalmia syndromic type 7 (MCOPS7). Three transcript variants encoding the same protein have been found for this gene.
Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)
Wimplinger, I., et al. Mol. Vis. 13, 1475-1482 (2007)
Wimplinger, I., et al. Am. J. Hum. Genet. 79(5):878-889(2006)
Nakashima-Kamimura, N., et al. J. Cell. Sci. 118 (PT 22), 5357-5367 (2005)
Prakash, S.K., et al. Hum. Mol. Genet. 11(25):3237-3248(2002)
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