HCCS Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | P53701 |
Other Accession | Q5F339, A5PJG7 |
Reactivity | Human |
Predicted | Bovine, Chicken |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 30602 Da |
Antigen Region | 173-200 aa |
Gene ID | 3052 |
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Other Names | Cytochrome c-type heme lyase, CCHL, Holocytochrome c-type synthase, HCCS, CCHL |
Target/Specificity | This HCCS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 173-200 amino acids from the Central region of human HCCS. |
Dilution | WB~~1:4000 IHC-P~~1:50~100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | HCCS Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | HCCS (HGNC:4837) |
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Synonyms | CCHL |
Function | Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome. |
Cellular Location | Mitochondrion inner membrane. Membrane; Lipid-anchor |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is an enzyme that covalently links a heme group to the apoprotein of cytochrome c. Defects in this gene are a cause of microphthalmia syndromic type 7 (MCOPS7). Three transcript variants encoding the same protein have been found for this gene.
References
Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)
Wimplinger, I., et al. Mol. Vis. 13, 1475-1482 (2007)
Wimplinger, I., et al. Am. J. Hum. Genet. 79(5):878-889(2006)
Nakashima-Kamimura, N., et al. J. Cell. Sci. 118 (PT 22), 5357-5367 (2005)
Prakash, S.K., et al. Hum. Mol. Genet. 11(25):3237-3248(2002)
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