|Application ||WB, IHC-P, E|
|Calculated MW||41021 Da|
|Antigen Region||91-119 aa|
|Other Names||Cytosolic 5'-nucleotidase 1A, cN1A, Cytosolic 5'-nucleotidase IA, cN-I, cN-IA, NT5C1A|
|Target/Specificity||This 5NT1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91-119 amino acids from the N-terminal region of human 5NT1A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||5NT1A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.|
|Tissue Location||Highly expressed in skeletal muscle. Detected at intermediate levels in heart, brain, kidney and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates.
Landers, J.E., et al. Proc. Natl. Acad. Sci. U.S.A. 106(22):9004-9009(2009)
Lechward, K., et al. Acta Biochim. Biophys. Sin. (Shanghai) 41(4):280-284(2009)
Fyrberg, A., et al. Nucleosides Nucleotides Nucleic Acids 25 (9-11), 1201-1204 (2006) :
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