|Application ||WB, FC, E|
|Calculated MW||64030 Da|
|Antigen Region||454-483 aa|
|Other Names||Arylsulfatase I, ASI, 316-, ARSI|
|Target/Specificity||This ARSI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 454-483 amino acids from the C-terminal region of human ARSI.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ARSI Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts.|
|Cellular Location||Secreted. Endoplasmic reticulum Note=Localized in the intracellular granular structures|
|Tissue Location||Expressed in placenta, in embryonic stem cells, fetal eyes and lens.|
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Provided below are standard protocols that you may find useful for product applications.
Sulfatases (EC 188.8.131.52), such as ARSI, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules
Oshikawa, M., et al. Mol. Vis. 15, 482-494 (2009)
Obaya, A.J. Gene 372, 110-117 (2006)
Sardiello, M., et al. Hum. Mol. Genet. 14(21):3203-3217(2005)
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