|Application ||WB, E|
|Other Accession||Q5RKI3, Q9QXE2, Q4R380|
|Predicted||Monkey, Mouse, Rat|
|Calculated MW||63482 Da|
|Antigen Region||549-575 aa|
|Other Names||DNA polymerase lambda, Pol Lambda, 4299-, DNA polymerase beta-2, Pol beta2, DNA polymerase kappa, POLL|
|Target/Specificity||This POLL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 549-575 amino acids from the C-terminal region of human POLL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||POLL Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|
|Tissue Location||Expressed in a number of tissues. Abundant in testis|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes.
Brown, J.A., et al. J. Mol. Biol. 395(2):282-290(2010)
van Loon, B., et al. Proc. Natl. Acad. Sci. U.S.A. 106(43):18201-18206(2009)
Garcia-Diaz, M., et al. Nat. Struct. Mol. Biol. 16(9):967-972(2009)
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