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RERE Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, IHC-P, E |
|---|---|
| Primary Accession | Q9P2R6 |
| Other Accession | Q62901, Q80TZ9 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 172424 Da |
| Antigen Region | 383-409 aa |
| Gene ID | 473 |
|---|---|
| Other Names | Arginine-glutamic acid dipeptide repeats protein, Atrophin-1-like protein, Atrophin-1-related protein, RERE, ARG, ARP, ATN1L, KIAA0458 |
| Target/Specificity | This RERE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-409 amino acids from the N-terminal region of human RERE. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RERE Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RERE |
|---|---|
| Synonyms | ARG, ARP, ATN1L, KIAA0458 |
| Function | Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:10814707, ECO:0000269|PubMed:11331249}. Note=Localized in nuclear bodies of variables size. Colocalized with PML and BAX in nuclear PODs |
| Tissue Location | Widely expressed. Expressed in tumor cell lines. |
Provided below are standard protocols that you may find useful for product applications.
Background
RERE encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development.
References
Zhang, H., et al. Osteoporos Int 20(2):341-346(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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